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Title Determinants of
ovarian volume in pre-, menopausal transition, and post-menopausal
women: A population-based study
Author Carlos Agostinho
Bastosa, c, Karen Oppermanna, c, Sandra Costa Fuchsb,
Giovana B. Donatoc and Poli Mara Spritzerd
Subject Determinants of
ovarian volume in pre-, menopausal transition, and post-menopausal
women: A population-based study
Institute of Research
Date Issue
Keyword Ovarian volume;
Menopausal status; Body mass index; Smoking; Parity
Abstract
Objective: To verify the association of smoking, parity,
body mass index, use of oral contraceptives, and hormone therapy
with ovarian volume in pre-, menopausal transition,
and post- menopausal women from southern
Brazil.
Methods: Cross-sectional study with 273 women aged
36?C62 years, representative of the urban population of Passo
Fundo, southern Brazil. Participants completed an in-home
interview and had their anthropometric measurements and ultrasound
exams performed at a clinical center, using a standardized
method. The right and left ovaries were measured by ultrasound.
Mean ovarian volume was calculated according to age, menopausal
status, smoking habit, parity, body mass index (BMI), use
of oral contraceptives (OC), and hormone therapy (HT).
Results: Ovarian volume decreased after the age of
44 years when adjusted for menopausal status
and OC use (p = 0.010). The mean ovarian volume decreased
with menopausal status adjusted for age (p
= 0.001) and with current OC use, adjusted for age (p = 0.001).
There was a positive association between ovarian volume and
BMI ?? 30 in every woman adjusted for menopausal
status and age (p = 0.005). On the other hand, there was no
association with smoking, past OC use, and HT. In a linear
regression model, post-menopause, menopausal
transition, age, and BMI were significantly and independently
associated with ovarian volume.
Conclusion: Ovarian volume decreases with menopausal
transition and even more in post-menopause. The reduction
of ovarian volume also occurred with aging and OC use. Ovarian
volume, however, is positively associated with obesity. Smoking,
parity, and hormone treatment do not affect ovarian volume
in pre-, menopausal transition, and post-
menopausal women.
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