Clinical Study & Practice on Pueraria mirifica
Herbal Breast Enlargement by Pueraria mirifica

Toxicity Study

Toxicity study of Pueraria mirifica has recently been conducted in male and female Wistar rats by the Medicinal Plant Research Institute, Department of Medical Sciences, Ministry of Public Health and by the Department of Biology, Faculty of Science, Chulalongkorn University.

The animals were given the suspension of root powder in water orally at the dose range between 10-1000 milligrams per kilogram of body weight per day continuously for a period of ninety days.

From the animal toxicity study, no estrogenic effect was observed at the doses of 10 mg/kg/day. The histopathological studies and biochemical data at different dose levels in rats of both sexes suggested that the maximum tolerated dose in rats would be around 100 mg/kg/day. When consider the uncertainty factor for the difference in the species and sensitivity among individuals, it is concluded that the safe dosage of Pueraria mirifica as a dietary supplement for human should be about 1-2 mg/kg/day, or about 50-100 mg/day.

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